Wegovy® vs. Saxenda®: Which is the best option for weight loss?

What you’ll learn:   

• Wegovy^® and Saxenda^® are GLP-1 receptor agonists that are FDA-approved for weight loss.
• Saxenda is taken as a daily injection, while Wegovy is taken once weekly.
• Clinical trials suggest that Wegovy^® could lead to greater weight loss than Saxenda.     
• Choosing between Wegovy^® and Saxenda^® should be based on individual health profiles, lifestyle, and weight loss goals in coordination with a doctor.

If you’ve been trying to lose weight but haven’t found the results you’re looking for, you might be thinking about your medication options. These days, the choices can be confusing and a bit overwhelming. Medications fall into categories, but even within the same category, medications can work in different ways and have varying costs. While Wegovy^® and Saxenda^® are both considered GLP-1 medications and are FDA-approved for weight loss, there are important differences to consider when choosing between them.

Ultimately, the one your doctor prescribes for you will depend on your health history, lifestyle, and weight loss goals. If you qualify for Noom Med, our clinicians can go through all the options to help you find the right one and then prescribe it if needed. Plus, you’ll get access to expert-guided plans combined with medical support to help you reach your goals.

Curious to see how Wegovy^® and Saxenda^® stack up? We’ll break it all down so you can choose the best option.

Wegovy^® vs. Saxenda^®: The similarities and differences

Wegovy^® and Saxenda^® are both GLP-1 receptor agonists. What this means is that their active ingredients mimic the GLP-1 hormone. This action helps reduce appetite, slows digestion, and regulates blood sugar. Both medications signal to your brain that you’re full, reduce cravings, helping you feel satisfied longer after meals. Most people are able to eat less without feeling deprived.

While they work similarly, they have different active ingredients.

• Wegovy^®’s active ingredient is semaglutide, which is also in Ozempic^® and Rybelsus^®, FDA-approved treatments for type 2 diabetes that are sometimes prescribed off-label for weight loss.
• Saxenda^®’s active ingredient is liraglutide, which is also in Victoza^®, a treatment for type 2 diabetes. It is also occasionally prescribed off-label for weight loss. Liraglutide is also available in generic form. 

Wegovy^® vs. Saxenda^®: Who can take them?

• Both medications are approved for adults with a BMI of 30 or higher or a BMI of 27 or higher if they also have a weight-related condition, such as high blood pressure, type 2 diabetes, or high cholesterol. Find out what your BMI is here.
• Wegovy has also been approved to reduce cardiovascular risks in adults with heart disease who have the same BMI as stated above.

Wegovy^® vs. Saxenda^®: How are they taken?

Wegovy^® and Saxenda^® are both injected into the upper arm, thigh, or belly using a pre-loaded injector pen. However, the frequency and dosing are different. The biggest difference is that Wegovy^® only requires a weekly injection, while Saxenda^® must be injected once per day.

• Wegovy^®:
  • Schedule: Once-weekly injection 
  • Starting dose: 0.25 mg once per week. Gradually increased over time to 0.5 mg, 1.0 mg, 1.7 mg, and then 2.4 mg (the maximum dose)
• Saxenda^®:
  • Schedule: Daily injection
  • Starting dose: 0.6 mg once per day. Gradually increased to 1.2 mg, 1.8 mg, 2.4 mg, and finally 3.0 mg (the maximum dose)

Wegovy^® vs. Saxenda^®: How much weight can I lose?

Wegovy^® and Saxenda^® have been extensively studied for their effectiveness in promoting weight loss. Here’s what you can expect to lose when combined with healthy lifestyle changes like diet and exercise.:

• Wegovy^®: In a two-year clinical trial, people who used semaglutide lost an average of 15% of their body weight. In comparison, the placebo group only lost under 3%.
• Saxenda^®: In a year-long study, 85% of adults who used liraglutide lost weight. Here’s a closer look at the results:
  • Over half lost at least 5% of their starting body weight.
  • One in three participants lost 10% or more of their body weight.

If your primary goal is to achieve the most significant weight loss possible, Wegovy^® may be the better choice. Keep in mind that your actual results will still depend on your individual health profile, lifestyle, and adherence to your weight management plan.

Wegovy^® vs. Saxenda^®: What do they cost?

The cost of medication can be a significant factor when deciding which is right for you. In general, Wegovy^® and Saxenda^® have similar list prices, but you may find one that is more affordable depending on your insurance. Keep in mind that weight loss medications are not typically covered by insurance. 

 Here’s how they compare:

• Saxenda^®: The list price for a month’s supply of Saxenda^® is about $1,350. However, your out-of-pocket cost may vary depending on factors like insurance coverage, pharmacy discounts, and manufacturer savings programs. 
• Wegovy^®: The list price for Wegovy^® is also $1,350 per month. Like Saxenda^®, your final cost will depend on your insurance plan and any available discounts or rebates. 

If you qualify for Noom Med, you can ask your clinician about compounded semaglutide* through Noom GLP-1^Rx. It has the same active ingredient as Ozempic^® and Wegovy^® but can be more affordable for some people. If prescribed by your clinician, it will cost $149 for the first month and $279 per month after that (billed in three-month increments.) With the medication, you’ll also get medical guidance, coaching, and access to all of Noom’s trackers, recipes, a catalog of exercises for people of all fitness levels, and more. 

Wegovy^® vs. Saxenda^®: Will I be able to find them in stock?

If you’re considering Wegovy^® or Saxenda^®, availability is an important factor, especially with the ongoing demand for GLP-1 medications. The Food and Drug Administration (FDA) is actively monitoring drug availability and working to address supply challenges. Here’s the most recent update:

• Wegovy^® (semaglutide):
  • Current status: In shortage. The manufacturer has reported that all dosage presentations are available, but supplies remain limited in many areas due to high demand.
• Saxenda^® (liraglutide):
  • Current status: In shortage. Saxenda is still in shortage and might be difficult to find. The generic version of liraglutide is available and might be an option.

What does “available” mean, according to the FDA?

When a manufacturer reports a drug presentation as “available,” it means they are releasing supplies, but the FDA clarifies that this doesn’t necessarily indicate the shortage has been resolved. Availability can still vary significantly depending on your pharmacy and location.

Tips for managing shortages:

• Check multiple pharmacies: Stock levels can vary from one location to another, so calling around can help you locate your prescription.
• Discuss alternatives: Your clinician can help you explore alternative medications or dosing options if your preferred prescription isn’t available. If you are a Noom Med member, your clinician can go through all the options available.
• Stay informed: Pharmacies and healthcare providers often receive updates on restock timelines. Manufacturer websites may also provide real-time updates on availability.

Wegovy^® vs. Saxenda^®: Safety considerations

While Wegovy^® and Saxenda^® can be effective tools for weight loss, it’s important to understand their potential side effects and who might need to avoid them to ensure safe use.

Common side effects of Wegovy^® and Saxenda^®

Most people experience mild side effects when starting Wegovy^® or Saxenda^®. These side effects are typically temporary and improve as your body adjusts:

• Nausea: The most common side effect for both medications, often mild to moderate. It’s more likely when you first start the medication or increase your dosage, but it usually fades over time.
• Diarrhea: You may experience loose or frequent stools as your digestive system adapts to the medication.
• Constipation: Some people experience slower digestion, which can lead to constipation. Staying hydrated and eating fiber-rich foods can help.
• Vomiting: Some may experience occasional vomiting, especially during the early stages or dose increases.
• Abdominal pain: Mild to moderate discomfort or cramping in the stomach area can occur, affecting around 20% of users.
• Headaches: Some users report headaches during the first few weeks of treatment.
• Injection site reactions: Mild redness, swelling, or irritation at the injection site is possible but generally resolves quickly.
• Fatigue: Both medications can cause tiredness, especially during the initial weeks of treatment.
• Low blood sugar (hypoglycemia): This is more common in people with diabetes who take glucose-lowering medications. Symptoms include shakiness, sweating, and confusion.
• Increased heart rate: Both medications may cause an increase in heart rate or palpitations.

Serious side effects and warnings

Though rare, serious side effects can occur with Wegovy^® and Saxenda^®. Get immediate medical attention if you experience any of the following:

• Pancreatitis: Symptoms include severe abdominal pain that may radiate to your back, along with nausea and vomiting.
• Gallbladder issues: These include gallstones or gallbladder infections. Watch for upper-right abdominal pain, nausea, fever, or yellowing of the skin or eyes (jaundice).
• Kidney problems: Dehydration from nausea, vomiting, or diarrhea can lead to decreased urination, swelling in the legs or feet, and fatigue.
• Allergic reactions: Seek immediate medical attention if you experience a rash, itching, swelling of the face or throat, or difficulty breathing.
• Vision changes: Blurry vision or sudden changes in eyesight may occur, especially in individuals with diabetes-related eye conditions (like diabetic retinopathy).
• Thyroid tumors: Both medications carry a warning about a potential risk of thyroid C-cell tumors based on animal studies. Watch for unusual lumps or swelling in the neck or difficulty swallowing.
• Mental health changes: Some users may experience depression, anxiety, or thoughts of self-harm. Speak to your healthcare provider if you notice any new or worsening mental health symptoms. 

Who should avoid Wegovy^® or Saxenda^®?

These medications may not be suitable for everyone. Make sure to discuss your full health history with your clinician. You should avoid Wegovy^® or Saxenda^® if you:

• Are pregnant, trying to conceive, or breastfeeding: These medications are not for people who are pregnant, trying to conceive, or breastfeeding.
• Have a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2): These conditions are associated with a higher risk of thyroid tumors.
• Have a history of pancreatitis: If you’ve had inflammation of the pancreas, these medications may increase your risk of recurrence.
• Have severe kidney or liver disease: Avoid these medications if you have significant kidney or liver impairment.
• Have gastroparesis (delayed stomach emptying): These medications can slow digestion further and worsen symptoms.
• Have type 1 diabetes: Neither Wegovy^® nor Saxenda^® is approved for managing type 1 diabetes.

For more information on the full list of side effects, visit Wegovy^® and Saxenda^®‘s official websites.

Staying safe while taking Wegovy^® or Saxenda^®

Here are some essential tips to help you stay safe and maximize results while taking Wegovy® or Saxenda®:

• Follow dosing instructions: Both medications require a gradual dose increase to help minimize side effects, which your clinician will monitor.
• Stay hydrated: Drink plenty of water to manage digestive side effects.
• Eat smaller, simpler meals: Avoid foods that can worsen nausea, such as fried or sugary foods.
• Monitor your health: Regular check-ins with your clinician can help catch any issues early and ensure you’re on the right track.

Use Noom’s GLP-1 Companion to guide you in making mindful food choices and managing side effects.

Wegovy^® vs. Saxenda^®: Making the best choice

Understanding the differences and similarities between Wegovy^® and Saxenda^® is the first step toward finding the right medication for your weight-loss journey. Both medications have proven to be effective tools when combined with lifestyle changes. The best choice for you will depend on your health history and goals.

If you’re a Noom Med member, our clinicians can guide you through your options, prescribe the right medication if appropriate, and support you with expert coaching, personalized plans, and tools to help you stay on track. Whether you’re navigating availability challenges, weighing costs, or managing side effects, you don’t have to do it alone.

At Noom, we’re here to empower you with the knowledge and resources to make informed decisions that work for your unique needs. Together, we can build sustainable habits and achieve your weight-loss goals with confidence.

*Compounded semaglutide available on the Noom platform is produced in an FDA-registered facility but not reviewed by the FDA for safety, efficacy, or quality.

Note: Ozempic^® is not FDA-approved to treat obesity or for weight loss.