What is metformin? Exploring the weight loss benefits, side effects, and cost

What you’ll learn:

• Metformin is a key medication for managing type 2 diabetes, helping to lower blood sugar levels and prevent complications.
• Metformin can aid weight loss off-label by reducing appetite and enhancing insulin sensitivity.
• Metformin is widely available as a generic medication, making it an affordable option for many. 

If you’ve thought about using medication to support weight loss, chances are you’ve heard of Ozempic^®. While it’s widely known as a diabetes medication, sometimes prescribed off-label for weight loss, it’s not the only option. Metformin, another medication designed to treat type 2 diabetes, is also gaining attention for its potential to promote weight loss off-label. Could metformin be the right choice for you? Let’s explore the facts, who it’s best suited for, and the potential weight loss results.

If you’re ready to talk to an expert about weight loss medication, see if you qualify for Noom Med. Our qualified clinicians will help you find the medication that’s right for you, if needed, and provide personalized guidance and support. You’ll learn how to manage side effects, optimize your nutrition, and build healthy habits for long-term success.

How can Metformin cause weight loss?

Metformin has been used to treat type 2 diabetes for over half a century. But, recently, it has also been prescribed off-label for weight loss.

There are three main ways that metformin can cause weight loss:

• It increases levels of what researchers call an “anti-hunger” molecule. This is the same molecule that is produced after vigorous exercise, a time when hunger is naturally suppressed. 
• Metformin helps lower glucose production and improves insulin sensitivity, both of which aid in weight loss.
• It stabilizes blood sugar, which also normalizes insulin levels, helping to burn fat.
  

How is metformin taken?

Most people take metformin as a pill with a meal, usually once or twice a day. There’s also an extended-release version that you only need to take once a day, which can be handy if you have difficulty remembering to take medication. The key thing to remember is to take it with food. This can help reduce potential stomach issues.

How effective is metformin for weight loss?

Metformin isn’t primarily a weight loss drug, but it can help people lose some weight. In one study, people with BMIs over 27 lost an average of nearly 13 pounds in six months while taking metformin, or nearly 7% of body weight.

Metformin works best for weight loss when paired with healthy lifestyle changes. Combining it with a balanced diet and regular exercise can really boost results. Noom can help nail those lifestyle changes, making metformin more effective. 

What are the differences between metformin and other popular medications prescribed for weight loss?

Metformin and popular GLP-1 medications, like Ozempic®, Wegovy®, Zepbound®, and Mounjaro®, are all effective for weight loss, but they achieve results through different pathways. For one, metformin is the active ingredient and not the brand name like these other medications. Side effects, pricing, and how they are taken will also vary. Here’s a look at them side by side:

Brand name	Glucophage®	Mounjaro®	Zepbound®	Ozempic®	Wegovy®
Active ingredient	Metformin	Tirzepatide	Tirzepatide	Semaglutide	Semaglutide
FDA-approved use(s)	Type 2 diabetes management	Type 2 diabetes management	Chronic weight management	Type 2 diabetes management	Chronic weight management
Administration	Oral tablet or liquid taken 1-2 times daily	Injection, once weekly	Injection, once weekly	Injection, once weekly	Injection, once weekly
How it works	Decreases glucose production in the liver, regulates blood sugar, and decreases appetite	Mimics hormones GLP-1 and GIP, curbing appetite and regulating blood sugar	Same as Mounjaro®	Mimics hormone GLP-1, curbing appetite and regulating blood sugar	Same as Ozempic®
Cost per month (without insurance)	With Noom Med, $29 for the first month and $89/month for the next 3 months (billed in 3-month increments).	$1,000- $1,050	$1,059	$935	$1,350
Common side effects	Nausea, vomiting, diarrhea, decreased appetite, stomach pain, constipation, metallic taste in mouth	Nausea, vomiting, heartburn, constipation, diarrhea, and bloating	Same as Mounjaro	Nausea, diarrhea, vomiting, constipation, abdominal pain, and fatigue	Same as Ozempic

What are the additional benefits of metformin beyond diabetes and weight management? 

Metformin might be prescribed for other conditions: 

• It is sometimes prescribed, in conjunction with another drug, for people with PCOS (polycystic ovary syndrome). 
• It can provide various benefits for people with PCOS trying to conceive, including ovulation stimulation, helping regulate periods, and to reduce the risk of miscarriage. 
• It may also have long-term benefits like improving cardiovascular health and lowering cholesterol. 

What does metformin cost?

The cost of metformin can vary depending on the specific dosage and where you get your prescription filled. But metformin is typically $10-30 for a 30-day supply. 

If you qualify for Noom Med, your clinician will determine if a prescription for metformin is right for you. If prescribed, you’ll pay $29 for the first month and $89 per month after that (billed in three-month increments). This one price covers your medication, ongoing clinical support, and full access to Noom’s behavior change program and tools. Check your eligibility here.

Metformin side effects and safety considerations

Metformin is generally well-tolerated, but like any medication, it can have side effects. Knowing what to expect can help you and your doctor decide if metformin is a good fit for you.

What are the common side effects of taking metformin?

Here are some things you might experience when taking metformin:

• Gastrointestinal issues: You might experience nausea, diarrhea, or stomach discomfort. These symptoms are common when starting metformin or increasing the dose. 
• Metallic taste: Some people notice a metallic taste in their mouth. 

These side effects usually improve as your body adjusts to the medication. Should any of these side effects persist or become troublesome, reach out to your doctor.

What are the potential serious side effects of taking metformin?

Less frequent but potentially more serious side effects can occur with metformin. Here are the ones to consider and how often people experience them. Always contact your doctor right away if you suspect any of these conditions:

Serious Side Effect	Symptoms	Frequency
Lactic acidosis	Severe muscle pain, drowsiness, slow or irregular heartbeat, cold or blue skin, dizziness, fast or difficulty breathing, stomach pain with nausea and vomiting	Rare.
Hypoglycemia (low blood sugar)	Shakiness, nervousness, sweating, chills, irritability, confusion, rapid heartbeat, dizziness, weakness, hunger, nausea, headache, and blurred vision	Rare, more likely when combined with other medications
Vitamin B12 deficiency	Fatigue, weakness, constipation, loss of appetite, nerve problems (numbness or tingling in hands and feet), yellowish skin	Rare, more likely with long-term use or in individuals with risk factors

Are there any health issues that make metformin unsuitable for me?

We’ve talked about how metformin is generally safe, affordable, and effective for weight loss, but there are a few situations where it might not be the best fit for you. As always, talk to your doctor about your health history before starting metformin. They’ll be able to figure out if it’s right for you and keep an eye on how things are going.

Here are some situations where metformin might not be recommended:

• Kidney problems: If you have severe kidney disease or your kidneys aren’t working as well as they should, metformin might not be the best choice. This is because metformin is mainly removed from your body through your kidneys.
• Metabolic acidosis: This is a condition where there’s too much acid in your blood. If you have acute or chronic metabolic acidosis, including diabetic ketoacidosis (DKA), metformin could potentially worsen the situation.
• Liver problems: If your liver isn’t functioning properly, it might not be able to process metformin effectively, which could lead to a buildup of the medication in your body.
• Pregnancy or breastfeeding: If you’re pregnant or breastfeeding, talk to your doctor before taking metformin. While it’s generally considered safe in these situations, your doctor can provide personalized guidance and discuss any potential risks or adjustments to your medication.
• Upcoming surgery or procedures with contrast dye: If you’re scheduled for surgery or an imaging procedure that requires contrast dye, you might need to temporarily stop taking metformin to reduce the risk of complications.

If any of these situations apply to you, don’t worry! There are alternative medications and approaches that might be a better fit for your unique needs. Your doctor or Noom Med can help you identify the best options and develop a personalized plan that prioritizes your safety. 

How Noom can help you succeed with metformin

Medication is just one part of the equation. By combining metformin with Noom’s proven approach, you’re more likely to achieve sustainable weight loss. The program helps you develop healthy habits, understand your relationship with food, and make lasting lifestyle changes while the medication supports your efforts. Noom Med’s program supports your success with metformin through:

• Medical guidance: Our clinicians will create a personalized weight loss program for you and help you manage any side effects.
• Behavioral psychology: You will learn the best ways to build lasting healthy habits
• Holistic support: You will have access to Noom’s tracking tools, a fitness library with thousands of on-demand workouts, educational resources, and an active, supportive community.

Want to learn if metformin with Noom Med might be right for you? Take our quiz to check your eligibility and get started on your weight loss journey today.

Note: Metformin and Ozempic® are not FDA-approved to treat obesity or for weight loss.