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Ozempic vs. Mounjaro: Which is the best option for weight loss?

1 min Read

Ozempic vs Mounjaro: Find out which GLP-1 medication is right for your weight loss goals. Explore their differences, benefits, and side effects.

What you’ll learn:

  • Both Ozempic and Mounjaro are effective for weight loss, with Mounjaro potentially offering greater results.
  • Ozempic and Mounjaro can be prescribed off-label for weight loss, but they are not FDA-approved for it.
  • They work differently: Mounjaro targets two weight-loss-related receptors, while Ozempic targets only one.

At Noom, we get it. Losing weight can be incredibly tough, and willpower alone often isn’t enough. Now, a new era of weight loss medications is making it easier than ever to achieve lasting weight loss. These highly effective medications, called GLP-1 receptor agonists, make you feel less hungry by slowing digestion and regulating blood sugar. These actions make weight loss easier, especially for those who have had difficulty losing weight. 

Ozempic and Mounjaro are two such medications. They are FDA-approved for managing type 2 diabetes but can also be prescribed for off-label use to promote weight loss. And even though they are similar, there are some huge differences in the way they work, how effective they are for weight loss, and their side effects.

Navigating your options can be confusing. That’s why if you qualify, the Noom Med program will pair you with a clinician who can help find the right medication for you and coordinate a prescription and benefits. Through Noom Med you will also have access to personalized support to help you manage the physical and mental aspects of losing weight. We’re here to help you overcome obstacles and build sustainable habits for a healthier life. 

Ozempic vs. Mounjaro: How do they work?

To determine which medication might be best for you, it’s essential to understand how each one works and what makes them different. The comparison below provides a helpful starting point for discussing your options with your doctor.

Approved usesFDA-approved for diabetes management only, but can be prescribed off-label for weight lossSame
Active ingredientsemaglutidetirzepatide
How it’s takenOnce-weekly injectionSame
What it doesHelps you feel fuller longer, slowing digestion, and regulating blood sugarSame
How it worksMimics the GLP-1 hormone, a naturally occurring hormone that signals to the brain that you feel full and satisfiedMimics the GLP-1 hormone and another gut hormone called GIP, which helps maintain blood sugar levels and has been shown to affect appetite and body weight

One important note: Ozempic and Mounjaro work best alongside the comprehensive lifestyle changes you’ll learn using Noom. Your healthcare provider or Noom Med can guide you in deciding if Ozempic or Mounjaro are appropriate choices for your individual needs and goals.

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Ozempic vs. Mounjaro: Which is better for weight loss?

When choosing between Ozempic and Mounjaro for weight loss, how well they work is a key consideration. Both medications have demonstrated impressive results in clinical trials, but how do they compare?

One study found that tirzepatide (Mounjaro) was up to three times more effective than semaglutide (Ozempic) for weight loss. This remarkable effectiveness of tirzepatide is likely due to its dual action on both GLP-1 and GIP receptors.

While Mounjaro may provide greater weight loss benefits, it’s crucial to also consider cost, insurance coverage, and potential side effects. Consulting with a healthcare professional can help you determine which medication best suits your individual needs and circumstances. Here’s how they compare:

Ozempic (semaglutide)Mounjaro (tirzepatide)
Weight loss effectivenessIn a clinical trial, participants who took semaglutide lost an average of 15% of their initial body weight over 68 weeks, compared to 2.4% in the placebo group.In a study involving tirzepatide, participants achieved an average weight loss of 22.5% over 72 weeks, surpassing the results seen with Ozempic.
How much do they cost?$900-1,300 average monthly cost.$1,000-1,200 average monthly cost.
Insurance considerationsNot FDA-approved for weight loss, so insurance may not cover it.Same.

Ozempic vs. Mounjaro: Most common side effects

While both Ozempic and Mounjaro are effective for weight loss, they also come with potential side effects and other risks. Let’s explore the most common side effects of each medication and how to manage them.

Side EffectOzempic (semaglutide)Mounjaro (tirzepatide)Management Strategies
Nausea and vomitingCommonCommonEat smaller meals, avoid fatty foods, and stay hydrated.Consult your doctor if vomiting persists or becomes severe.
ConstipationCommonLess common than OzempicBoost your fiber consumption, stay well-hydrated, and incorporate daily exercise.
DiarrheaCommonMore common than OzempicStay hydrated, eat bland foods, and consider over-the-counter medications
Stomach painUncommonMore common than OzempicConsult your doctor if the pain persists or becomes severe
FatigueCommonCommonEat a balanced diet, move more, and prioritize sleep

How to manage side effects

Typically, the most common, milder side effects of Ozempic and Mounjaro can be managed through lifestyle modifications. To lessen the likelihood of side effects, be sure to maintain a nutrient-dense diet and maintain a regular exercise schedule. Some foods have been shown to aggravate the uncomfortable stomach-related effects of GLP-1s. Your healthcare provider will work with you to check the correct starting dose and adjust it as needed based on how you feel. 

It is also important to note that the rapid weight loss that occurs when taking medications like Ozempic and Mounjaro can result in the loss of important muscle mass. This can be slowed through lifestyle changes like eating more protein and increasing exercise. Noom Med or the GLP-Companion can guide you in the right direction in terms of the best food choices and movement plans.

Ozempic vs. Mounjaro: Serious side effects

More serious side effects for both Ozempic and Mounjaro are similar and include: 

  • inflammation of the pancreas (pancreatitis)
  • low blood sugar
  • serious allergic reactions
  • kidney problems
  • severe stomach problems
  • changes in vision
  • gallbladder problems
  • thyroid tumors/cancer

While these side effects are relatively rare, it is important to monitor for signs of these issues and get immediate medical care if you suspect them.

At Noom, we understand that managing side effects can be a challenge when starting a new medication. If you qualify, Noom Med will provide comprehensive support to help you navigate the ups and downs of your weight loss journey. With personalized coaching, educational resources, and a supportive community, you’ll have the tools and guidance you need to stay on track and reach lasting success.

If you’re considering Ozempic for weight loss, check out our article on how to get Ozempic for weight loss to learn more about the process and what to expect.

Other medications to ask your doctor about

Ozempic and Mounjaro are not FDA-approved for weight loss, which could impact insurance coverage. If that is the case, look into these alternatives:

  • Wegovy: Wegovy has the same active ingredient (semaglutide) as Ozempic and is FDA-approved for weight loss if you meet certain criteria. The dosage is slightly higher and its results are similar to Ozempic, with an average weight loss of 15% of body weight.
  • Zepbound: Zepbound has the same active ingredient as Mounjaro (tirzepatide) and is FDA-approved for weight loss. It can help with weight loss of up to 20% of body weight.

How Noom can help support your weight loss journey

Selecting the right weight loss tools is key. Your health profile, medical history, and personal goals are all important factors in finding the best solution for you. At Noom, we prioritize personalized care and we have a variety of programs that can help.

If you qualify for Noom Med, we will pair you with a dedicated healthcare professional who can assess your unique needs. They will work with you to create a customized treatment plan that might include a medication like Ozempic or Mounjaro.

If you have already been prescribed weight-loss medication, you can choose the GLP-1 Companion. This will help you improve your diet, encourage daily movement, and track side effects. 

Note: Ozempic and Mounjaro are not FDA-approved to treat obesity or for weight loss.