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Ozempic vs. Trulicity: Which is the best option for weight loss?

1 min Read

What you’ll learn: You’ve likely heard of Ozempic. You might also know that it was developed to treat diabetes and is now prescribed off-label to help people lose weight. What you might not know is that Trulicity is very similar, and was developed several years before the Ozempic. If you’re considering medication to help with […]

What you’ll learn:

  • Both Ozempic and Trulicity can aid in weight loss by mimicking a natural hormone that curbs appetite.
  • Both medications effectively manage blood sugar and help with weight loss.
  • Ozempic may be more effective for weight loss for some people.

You’ve likely heard of Ozempic. You might also know that it was developed to treat diabetes and is now prescribed off-label to help people lose weight. What you might not know is that Trulicity is very similar, and was developed several years before the Ozempic. If you’re considering medication to help with weight loss, it’s good to know the similarities and differences between these two options.

Both are classified as GLP-1 receptor agonists, which mimic the effects of the hormone your body naturally produces. That hormone (not surprisingly) is called GLP-1, and it naturally helps control appetite, slows gastric emptying, and stabilizes blood sugar levels. But how effective are Ozempic and Trulicity for weight loss, and could one of them be the right option for you?

Possibly! Here’s the thing… even with consistent diet and exercise, hormonal imbalances and other factors beyond your control can hinder your weight loss efforts. Ozempic and Trulicity offer a potential solution by working with your body to target these underlying issues. Of course, they work most effectively as part of Noom’s holistic approach which includes a balanced diet, daily exercise, and personalized support. 

Here’s how they work, potential side effects, and other things to consider before asking your doctor about them.

Ozempic vs. Trulicity: How do they work?

Though Ozempic and Trulicity contain two different active ingredients, semaglutide versus dulaglutide, they work similarly to manage blood sugar and weight. However, subtle differences between these two medications could make one a better fit for you. Let’s break them down to help you discuss the best option with your doctor.

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Approved UsesApproved for adults with type 2 diabetes, but can be prescribed off-label for weight lossApproved for adults and certain children ages 10 years and older with type 2 diabetes. Can be prescribed off-label for weight loss.
Active IngredientSemaglutideDulaglutide
How it’s takenOnce-weekly injectionSame
What it doesHelps you feel fuller, longer, slows digestion, and helps control blood sugarSame
How it worksMimics the GLP-1 hormone, a naturally occurring hormone that signals to the brain that you feel full and satisfied, while also stimulating insulin production to help regulate blood sugar levels in people with type 2 diabetes.Mimics the GLP-1 hormone, with similar effects on appetite and blood sugar control, but has a different molecular structure and doesn’t work as long in the body as semaglutide.
Typical starting doses0.25 mg weekly, gradually increased to 0.5 mg, then 1 mg if needed. Maximum dose: 2 mg weekly. 0.75 mg weekly, may be increased to 1.5 mg after 4 weeks. Maximum dose: 4.5 mg weekly.

Unsure whether to ask your doctor about Ozempic or Trulicity? The Noom Med program can connect you with a healthcare provider who will help you figure out which weight loss medication is right for you and help you set realistic health goals. 

Ozempic vs. Trulicity: Which is better for weight loss?

When considering Ozempic and Trulicity for weight loss, there are some differences in their performance and accessibility. While Ozempic may offer a slight edge in weight loss for some, Trulicity may be a better fit for others based on factors like insurance coverage or specific medical considerations. Talking to your doctor is the key to making an informed decision and achieving your health goals. Potential side effects will also come into play.

Comparison CriteriaOzempicTrulicity
Weight loss effectivenessIn a clinical trial, participants who took semaglutide lost an average of 15% of their initial body weight over 68 weeks, compared to 2.4% in the placebo group.Trulicity can also lead to weight loss, with its active ingredient dulaglutide leading to an average weight loss of 5-10% of body weight in one clinical trial. 
How much do they cost?$900-$1,300 average monthly cost, without insurance.$900-$1,500 average monthly cost, without insurance.
Insurance coverageNot FDA-approved for weight loss, so insurance may not cover it. Insurance coverage and costs can vary. Some plans may require prior authorization requirements. Co-pay assistance programs may be available for those who qualify.Same.

Ozempic vs. Trulicity: Side effects and risks

Both Ozempic and Trulicity can be effective for weight management, but they may also cause side effects. Most people experience mild side effects that improve over time, but it’s important to be aware of all possibilities.

Side EffectOzempic (semaglutide)Trulicity (dulaglutide)Management Strategies
Nausea, vomiting, or diarrheaCommonCommonEat smaller meals, avoid fatty foods, and stay hydrated. Your doctor may recommend starting with a lower dose and gradually increasing it.
ConstipationCommonCommonBoost fiber intake, stay hydrated, and exercise regularly.
Stomach painCommonCommonConsult your doctor if persistent or severe
Low blood sugarUncommonUncommonMonitor blood sugar closely, especially if on insulin or other diabetes medications
Injection site reactionsUncommonUncommonYour doctor can provide guidance on proper injection techniques to minimize skin reactions.

Ozempic vs. Trulicity: Rare but serious side effects

While rare, it’s important to be aware of these potentially serious side effects associated with GLP-1 receptor agonists like Ozempic and Trulicity. Be sure to discuss all potential side effects and your health history with your doctor before beginning either medication. If you experience any signs of the below side effects, get medical assistance immediately.

Side EffectOzempic (semaglutide)Trulicity (dulaglutide)Symptoms
PancreatitisRareRareSevere abdominal pain, nausea, vomiting
Gallbladder problemsRareRareAbdominal pain, fever, jaundice
Kidney problemsRareRareChanges in urine frequency or amount, swelling in your feet or ankles
Allergic reactionsRareRareDifficulty breathing, swelling of the face or throat, rash
Diabetic eye problemsRareRareChanges in vision, blurred vision, floaters, or dark spots
Thyroid C-cell tumors/cancersVery rareVery rareA lump or swelling in the neck, hoarseness, difficulty swallowing, or shortness of breath. Some studies suggest a potential association between GLP-1 receptor agonists and certain types of cancer.

When managing your health, prioritize making smart decisions that align with your specific needs and personal goals. Discuss with your healthcare team the possible pros and cons of medications like Ozempic and Trulicity to determine the best approach for you.

Finding your personalized path to better health

Ozempic and Trulicity can be powerful allies in managing blood sugar and potentially aiding in weight loss. However, it’s important to remember that these medications are just one piece of the puzzle. A holistic approach that considers your specific needs and health goals is necessary for long-term success.

At Noom, we’re committed to helping you achieve a healthier, happier life. Our comprehensive programs are designed to tackle the complexities of weight management and overall well-being. Whether you’re taking Ozempic, Trulicity, or other weight loss medications, our personalized approach can help you monitor your progress, manage potential side effects, and develop sustainable lifestyle changes. Let Noom empower you to take control of your health and unlock your full potential.

Note: Ozempic and Trulicity are not FDA-approved to treat obesity or for weight loss.