Safety information for Progesterone

Micronized progesterone is a bioidentical hormone that is molecularly identical to the progesterone produced by the ovaries prior to menopause.

Progesterone is prescribed for people with a uterus who are either using the estrogen patch or cream.

It is used with estradiol as an extra layer of safety to protect your uterine lining (endometrium) from overgrowth, which can lead to rare complications like endometrial cancer.

Note: Your progesterone pill is prepared with peanut oil. If you have a peanut allergy, don’t take it and reach out to your clinician to discuss alternatives.

Progesterone can make you feel calm or drowsy. Because of this, you should take the pill at bedtime, as close to the same time as possible.  Don’t drive or perform other activities that require coordination until you see how it affects you.

Swallow the pill whole. Do not crush or chew the pill.

You can take it with or without food.

Keep your progesterone in a cool, dry place at room temperature (68–77°F, or 20–25°C).

Avoid extreme temperatures, and don’t freeze or expose it to direct sunlight or heat sources, like radiators.

• Micronized progesterone is Food and Drug Administration (FDA)-approved and is considered safe if taken as prescribed by your clinician.
• Learn more about Noom’s commitment to safety and transparency here.

• Interactions
  • Progesterone may interact with certain medications or supplements. Always let your clinician know about any other medications or supplements that you’re currently taking.
• Side effects
  • All medications may cause side effects. However, many people experience only minor side effects, which usually resolve with time, or no side effects at all. Contact your clinician if these or any other side effects bother you or don’t go away.
• Common side effects
  • Breast tenderness
  • Mood changes
  • Bloating
  • Irregular vaginal bleeding
  • Nausea
  • Headache
  • Drowsiness
• Rare side effects
  • Severe allergic reaction (anaphylaxis)
  • Heart attack, stroke, or venous thromboembolism
  • Breast cancer
  • Gallbladder disease
  • Severe headaches
  • Liver abnormalities
  • Severe mood changes or depression
  • Unusual breast changes (e.g., lumps, severe tenderness)
  • Skin reactions (e.g., erythema multiforme, urticaria)