Safety information for Estrogen Body Cream(Biest 50/50)

The Estrogen Body Cream (Biest 50/50) is a compounded cream that delivers two types of estrogen, estradiol and estriol, through the skin and into the bloodstream.

The estradiol and estriol used in the cream are both bioidentical forms of natural estrogens, which means they are molecularly identical to hormones naturally produced by your body.

During the menopause transition, estrogen levels begin to fluctuate and progressively decline.

Estrogen regulates many functions in your body. So when these levels drop, you may experience symptoms like hot flashes, night sweats, and vaginal dryness.

The Estrogen Body Cream (Biest 50/50) can replenish your estrogen levels enough to reduce these symptoms. It may also help prevent long-term health conditions like osteoporosis, diabetes, heart disease, and colon cancer.

Choose your site.
Apply to a clean, hairless area like inner thighs or arms. Don’t use lotions, powders, or oils before application.

Dispense the cream.
Turn the base of the container to dispense the product the desired number of times, as prescribed. You will hear a “click” with each turn.

Apply the cream.
Use the device to rub cream into the skin.

Rotate sites if irritation occurs with use.

Try to apply the cream at the same time each day for maximum effectiveness.

After applying the cream, wait 60 minutes before swimming or bathing.

The estrogen body cream should be applied daily. If you miss a dose, just skip it and apply your prescribed dose the following day.

Get back on track as soon as possible and apply the cream at the same time daily.

Missing a few doses may cause spotting. Get back on track as soon as possible and apply the cream daily.

Keep your estrogen cream in a cool, dry place at room temperature (68–77°F, or 20–25°C).

Avoid extreme temperatures, and don’t freeze or expose it to direct sunlight or heat sources, like radiators.

• While the FDA does not evaluate compounded medications, for every compounded medication that we dispense, our partner pharmacies perform routine testing internally and through third-party Food and Drug Administration (FDA) and Drug Enforcement Administration (DEA)-registered labs to ensure a robust quality control process. They test key characteristics to ensure consistency and quality standards are met for every prescription. Certificates of analysis are available for each compounded medication dispensed, and we also keep track of patient outcomes to maximize safety.
• Learn more about Noom’s commitment to safety and transparency here.

• Risks
  • Taking estrogen can increase the risk of:
    • Endometrial cancer in women with a uterus, which can be prevented by adding progesterone.
    • Heart attack, stroke, or venous thromboembolism, which is largely avoided with transdermal formulations.
    • Dementia, according to some studies. Data from a large study indicated this risk is seen only in patients starting therapy at age 65 or older.
    • It can also increase breast density in some women, which makes it more challenging to detect abnormalities on mammograms and may require additional imaging.
    • HRT and Breast Cancer: Taking estrogen with certain forms of progesterone may slightly increase the risk of breast cancer in some women. This risk has been shown to be less for women under age 60 starting HRT within 10 years of menopause as well as for women using micronized progesterone (what we prescribe). Learn more on our HRT Safety & Transparency page.
• Interactions
  • Estrogen may interact with certain medications or supplements. Always let your clinician know about any other medications or supplements that you’re currently taking.
• Side effects
  • All medications may cause side effects. However, many people experience only minor side effects, which usually resolve with time, or no side effects at all. Contact your clinician or get medical help if these or any other side effects bother you or don’t go away.
• Common side effects
  • Breast tenderness
  • Mood changes
  • Bloating
  • Irregular vaginal bleeding
  • Nausea
  • Headache
• Rare adverse events
  • Severe allergic reaction (anaphylaxis)
  • Heart attack, stroke, or venous thromboembolism
  • Breast cancer
  • Gallbladder disease
  • Severe headaches
  • Liver abnormalities
  • Vision changes (e.g., retinal vascular thrombosis)
  • Severe mood changes or depression
  • Unusual breast changes (e.g., lumps, severe tenderness)
  • Ovarian cancer
  • Endometrial hyperplasia or cancer
  • Skin reactions (e.g., erythema multiforme, urticaria)