Microdosing GLP-1 medications for weight loss: Is it safe?

What you’ll learn:   

• Microdosing GLP-1 medications for weight loss lacks scientific evidence and could be dangerous.       
• Any use of a GLP-1 medication should be prescribed by a clinician in appropriate doses. 
• For sustainable weight loss, focus on evidence-based methods that emphasize long-term lifestyle changes supported by nutritional science and behavioral psychology.

Recently, people have been sharing stories about experimenting with small doses of GLP-1 medications, like Ozempic^®, for weight loss—a practice called microdosing. Microdosing involves taking smaller amounts of a medication to achieve some of its effects. While personalized dosing can be appropriate when carefully managed by a licensed healthcare provider, attempting it on your own or through unlicensed sources can be risky and unsafe.

Why? GLP-1 medications are only prescribed to those who meet certain medical criteria, and the dosages are carefully regulated to ensure safety and effectiveness. Despite this, some people have turned to microdosing, hoping to use smaller amounts of these often expensive medications to lose weight more affordably.

The problem? There’s no scientific evidence to support microdosing for weight loss, and self-dosing can be dangerous. Much of the information circulating comes from people obtaining medications through sources like “med spas” rather than licensed medical professionals.

When it comes to your health, relying on safe, proven methods matters most. If you qualify for Noom Med, your clinician can review all your medication options and help you find the right one for your needs and budget—without unnecessary risks. Let’s break down the dangers of microdosing and why it’s a trend you’ll want to skip.

What are GLP-1s and how do they work?

First, let’s talk about what GLP-1 medications are and how they work. The full name of these medications is GLP-1 receptor agonists because they mimic a hormone in your body called GLP-1. Here’s what they do:

• Reduce appetite: GLP-1s make it easier to control your food intake, which is key for long-term weight loss.
• Improve satiety: These medications also help you feel full for longer by slowing down the movement of food from your stomach.
• Regulate blood sugar GLP-1s help stabilize your blood sugar, which is why they were first used to treat type 2 diabetes.

How are they taken?

Most GLP-1s come in easy-to-use pens or in a vial and syringe format. They are injected into the upper arm, belly, or thigh. The doses are closely monitored and are adjusted as needed. Most people stay on them for at least six months, though the length of time can vary depending on health goals and progress.

What are the most popular GLP-1s?

• Wegovy^® and Ozempic^® (semaglutide): Wegovy^® is an FDA-approved medication for weight loss. Ozempic^® is approved to treat type 2 diabetes, but it can be prescribed off-label for weight loss.
• Zepbound^® and Mounjaro^® (tirzepatide): Zepbound^® is FDA-approved for weight loss. Mounjaro is approved for treating type 2 diabetes but can be prescribed off-label for weight loss.

If you’re considering GLP-1s, talk to your doctor to find out if a prescription is right for you. You can also see if you qualify for Noom Med. Our clinicians can help you determine the best medication for you and prescribe it if needed. 

Why are people microdosing GLP-1s instead of taking the full dose?

People are microdosing GLP-1 medications for a few different reasons. Here are some that they’ve mentioned:

• They don’t qualify for the medication: GLP-1 medications are typically prescribed only to people who meet specific criteria. They are only prescribed to people with a BMI of 30 or over or a BMI of 27 or over with a weight-related medication condition like high blood pressure or high cholesterol. Those who don’t qualify may turn to microdosing as an alternative, even though it’s not a medically supervised approach.
• Reduced side effects: Full doses of GLP-1 medications can cause side effects like nausea, vomiting, and fatigue. By microdosing, some hope to minimize these discomforts while still seeing some benefits.
• Lower costs: GLP-1 medications can be expensive, and insurance often doesn’t cover them. Some believe that taking smaller amounts might stretch their supply and reduce expenses.
• Fear of commitment: Some people are hesitant to start a full-dose regimen due to the long-term commitment involved. Microdosing can feel like a lower-risk way to “test the waters” without jumping into a formal treatment plan.
• Perception of control: Microdosing can create a sense of control over the process, allowing people to adjust their dosage based on how they feel rather than following a set prescription.

Why is microdosing GLP-1s risky?

Microdosing methods vary, but most people work with unlicensed providers to take smaller-than-recommended doses of medication at regular intervals. This could mean taking only a fraction of what’s typically prescribed for GLP-1 medications. Since GLP-1s are designed and tested in strict amounts for people with specific conditions, microdosing is risky. Here’s why:

• Lack of medical oversight: Using medications outside their intended purpose can pose unforeseen risks. GLP-1s are not recommended for people with certain health conditions, and severe side effects are possible. Always follow your doctor’s prescribing orders and the established guidelines for all medications. 
• Unproven effectiveness: No scientific evidence shows that microdosing can achieve any weight loss benefits. 
• Chance of getting the dose wrong: Brand-name weight-loss GLP-1 medications, like Wegovy^® and Zepbound^®, come in fixed-dose injectors, making personalized dose adjustments impossible without tampering with the pen. Using less or more of the prescribed medication in a vial and syringe format is also not safe.

The lack of evidence behind microdosing

The scientific community is still in the early stages of understanding microdosing for weight loss. Current research on this topic is limited, with most available information coming from anecdotal reports rather than comprehensive scientific studies. There is little evidence that taking smaller amounts of GLP-1 drugs for weight loss will work, and safety can’t be verified. 

When licensed clinicians personalize a dose, they use a certified compounding pharmacy. Licensed compounding pharmacies can prepare GLP-1 medications in customized doses based on your doctor’s prescription, ensuring the dose is precise, safe, and tailored to your needs. Attempting to adjust doses yourself can be dangerous and unpredictable.

Exploring safe and sustainable options

Your health journey deserves more than a short-term trend—it thrives on meaningful, lasting changes. Microdosing is not a safe solution for weight management. Always work with a licensed provider when taking medications. 

If you are interested in trying medications for weight loss, you have options. First, see if you qualify for Noom Med. You’ll get access to licensed clinicians who can prescribe GLP-1 medications if applicable. If cost is a concern, our clinicians can also prescribe compounded semaglutide* through Noom GLP-1^Rx if needed. Our compounded semaglutide is prepared in FDA-regulated 503B compounding pharmacies and contains the same active ingredient as Ozempic^® and Wegovy^® but at a potentially more affordable price. It starts at just $149 for the first month and includes medication, medical guidance, personalized coaching, and Noom’s science-backed program designed to help you create lasting changes. 

When embarking on a weight loss journey, it’s important to create routines that support your goals, keep you healthy, and fit your lifestyle. With a plan designed just for you, you can take the first step toward lasting change.

*Compounded semaglutide available on the Noom platform is produced in an FDA-registered facility but not reviewed by the FDA for safety, efficacy, or quality.

Note: Ozempic^® is not FDA-approved to treat obesity or for weight loss.